Neuro Ic Pharmacology

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Matching prototypes with contraindications, AEs, and drug-drug/food interactions.

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Norria Brice, DNP, RN, ACNP-BC

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Neuro Ic PharmacologyVersión en línea Matching prototypes with contraindications, AEs, and drug-drug/food interactions. por Norria Brice, DNP, RN, ACNP-BC 1 Prototype: Ergotamine (Ergomar) 2 Prototype: Sumatriptan (Imitrex) 3 Prototype: Diazepam (Valium) 4 Prototype: Phenobarbital (generic) 5 Prototype: Imipramine (Tofranil) 6 Prototype: Phenelzine (Nardil) Prototype: Ergotamine (Ergomar) Contraindications: coronary disease, HTN, peripheral vascular disease; impaired liver function; pregnancy/lactation. AEs: Numbness, tingling in fingers/toes, muscle pain in extremities, pulselessness/weakness in legs, tachycardia, bradycardia, ergotism. Drug-drug: peripheral ischemia/gangrene if given w/beta-blockers (-lol) Prototype: Sumatriptan (Imitrex) Contraindications: Pregnancy, active coronary artery disease exacerbated by vessel-constricting effects of this drug. AEs: Dizziness, vertigo, weakness, myalgia, BP alterations, tightness/pressure in chest, injection site discomfort, tingling, burning sensations, numbness Drug-drug: Risk of prolonged vasoactive reaction if given w/ergot type drugs; severe AEs if given w/MAOIs (separate by 2 wks) Prototype: Diazepam (Valium) Contraindications: Acute narrow-angle glaucoma, shock, coma, pregnancy (could cause congenital birth defects), lactation. AEs: mild drowsiness, depression, lethargy, Brady-/tachyarrhythmias, changes in libido, drug dependence. Drug-drug: Avoid ETOH & other CNS depressants Prototype: Phenobarbital (generic) Contraindicatons: Hepatic impairment, nephritis, pregnancy (potential for congenital defects); respiratory distress/dysfunction. AEs: Somnolence, agitation, confusion, hyperkinesis, ataxia, CNS depression, apnea,Stevens-Johnson syndrome. Drug-drug: Increased CNS depression if taken with ETOH, antihistamines, tranquilizers; do not combine w/MAOIs, anticoagulants, digoxin, oral contraceptives. Prototype: Imipramine (Tofranil) Contraindications: Recent MI (may worsen infarction or cause a recurrence), myelography within previous 24 hrs to next 48 hrs (interaction w/contrast dye), serious.AEs if given w/MAOIs, pregnancy/lactation. AE: sedation, anticholinergic effects, confusion, anxiety, urinary retention, bone marrow depression, CV effects. Drug-drug increase in TCA levels if given w/cimetidine, fluoxetine, ranitidine; increased risk of bleeding if given w/anticoagulants; risk of severe hyper pyretic crisis, convulsions, hypertensive episodes, death if given w/MAOIs). Prototype: Phenelzine (Nardil) Contraindicatons: Hx of pheochromocytoma; CV disease, HTN, coronary disease, angina, CHF; abnormal CNS vessels/defects AEs: DIzziness, vertigo, HA, hyperreflexia, tremors, mania, orthostatic hypotension, hypertensive crisis. Drug-drug: Risk of hypertensive crisis, coma, convulsions with given w/TCAs; Life-threatening serotonin syndrome w/SSRIs (separate by 6 wks), hypoglycemic effects if given w/antidiabetic agents.

Neuro Ic PharmacologyVersión en línea

Matching prototypes with contraindications, AEs, and drug-drug/food interactions.

por Norria Brice, DNP, RN, ACNP-BC

Prototype: Ergotamine (Ergomar)

Prototype: Sumatriptan (Imitrex)

Prototype: Diazepam (Valium)

Prototype: Phenobarbital (generic)

Prototype: Imipramine (Tofranil)

Prototype: Phenelzine (Nardil)

Prototype: Ergotamine (Ergomar)

Contraindications: coronary disease, HTN, peripheral vascular disease; impaired liver function; pregnancy/lactation.

AEs: Numbness, tingling in fingers/toes, muscle pain in extremities, pulselessness/weakness in legs, tachycardia, bradycardia, ergotism.

Drug-drug: peripheral ischemia/gangrene if given w/beta-blockers (-lol)

Prototype: Sumatriptan (Imitrex)

Contraindications: Pregnancy, active coronary artery disease exacerbated by vessel-constricting effects of this drug.

AEs: Dizziness, vertigo, weakness, myalgia, BP alterations, tightness/pressure in chest, injection site discomfort, tingling, burning sensations, numbness

Drug-drug: Risk of prolonged vasoactive reaction if given w/ergot type drugs; severe AEs if given w/MAOIs (separate by 2 wks)

Prototype: Diazepam (Valium)

Contraindications: Acute narrow-angle glaucoma, shock, coma, pregnancy (could cause congenital birth defects), lactation.

AEs: mild drowsiness, depression, lethargy, Brady-/tachyarrhythmias, changes in libido, drug dependence.

Drug-drug: Avoid ETOH & other CNS depressants

Prototype: Phenobarbital (generic)

Contraindicatons: Hepatic impairment, nephritis, pregnancy (potential for congenital defects); respiratory distress/dysfunction.

AEs: Somnolence, agitation, confusion, hyperkinesis, ataxia, CNS depression, apnea,Stevens-Johnson syndrome.

Drug-drug: Increased CNS depression if taken with ETOH, antihistamines, tranquilizers; do not combine w/MAOIs, anticoagulants, digoxin, oral contraceptives.

Prototype: Imipramine (Tofranil)

Contraindications: Recent MI (may worsen infarction or cause a recurrence), myelography within previous 24 hrs to next 48 hrs (interaction w/contrast dye), serious.AEs if given w/MAOIs, pregnancy/lactation.

AE: sedation, anticholinergic effects, confusion, anxiety, urinary retention, bone marrow depression, CV effects.

Drug-drug increase in TCA levels if given w/cimetidine, fluoxetine, ranitidine; increased risk of bleeding if given w/anticoagulants; risk of severe hyper pyretic crisis, convulsions, hypertensive episodes, death if given w/MAOIs).

Prototype: Phenelzine (Nardil)

Contraindicatons: Hx of pheochromocytoma; CV disease, HTN, coronary disease, angina, CHF; abnormal CNS vessels/defects

AEs: DIzziness, vertigo, HA, hyperreflexia, tremors, mania, orthostatic hypotension, hypertensive crisis.

Drug-drug: Risk of hypertensive crisis, coma, convulsions with given w/TCAs; Life-threatening serotonin syndrome w/SSRIs (separate by 6 wks), hypoglycemic effects if given w/antidiabetic agents.

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Neuro Ic PharmacologyVersión en línea

por Norria Brice, DNP, RN, ACNP-BC

Prototype: Ergotamine (Ergomar)

Prototype: Sumatriptan (Imitrex)

Prototype: Diazepam (Valium)

Prototype: Phenobarbital (generic)

Prototype: Imipramine (Tofranil)

Prototype: Phenelzine (Nardil)