Delayed Transfusion Reactions Matchup

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Group cause, prevention, treatment for each transfusion reaction type.

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Sara Smith

Estados Unidos

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Delayed Transfusion Reactions MatchupVersión en línea Group cause, prevention, treatment for each transfusion reaction type. por Sara Smith 1 Delayed HTR 2 Alloimmunization to RBC Antigens 3 Alloimmunization to HLA Antigen 4 Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD) 5 Post-Transfusion Purpura 6 Iron Overload/Transfusion Induced Hemosiderosis 7 Hematologic Events Associated with Transfusions Cause: recipient antibody to antigen on donor RBCs causing (mostly extravascular) hemolysis Prevention: check records, use fresh specimens for Ab screening and XM, use Ag-negative blood. Treatment: treat as necessary based on Sx, evaluate renal function, pay close attention to differential diagnosis with sickle cell patients (may resemble sickle crisis). Cause: immune response to foreign RBC antigens Prevention: Avoid unnecessary transfusio Cause: immune response to foreign antigens on WBCs and platelets Prevention: avoid unnecessary transfusion, give leuko-reduced or irradiated blood where indicated Cause: immunologically competent donor WBCs form antibodies to recipient antigens, mounting an immune response against the patient Prevention: irradiate blood products prior to transfusion Treatment: does not respond to most treatment regimens Cause: recipient antibody to platelets (usually anti-P1A1) Treatment: corticosteroids, plasmapheresis Prevention: transfuse P1A1 negative platelets in the future Cause: chronic transfusions leading to a build-up of excess iron in liver, heart, and endocrine glands Prevention: keep transfusions to a minimum, transfuse with neocytes Treatment: iron chelation therapy Cause: massive transfusion leads to low levels of platelets and/or coagulation proteins that do not survive blood storage conditions Prevention: monitor platelets during and after transfusion Treatment: administer platelets

Delayed Transfusion Reactions MatchupVersión en línea

Group cause, prevention, treatment for each transfusion reaction type.

por Sara Smith

Delayed HTR

Alloimmunization to RBC Antigens

Alloimmunization to HLA Antigen

Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD)

Post-Transfusion Purpura

Iron Overload/Transfusion Induced Hemosiderosis

Hematologic Events Associated with Transfusions

Cause: recipient antibody to antigen on donor RBCs causing (mostly extravascular) hemolysis

Prevention: check records, use fresh specimens for Ab screening and XM, use Ag-negative blood.

Treatment: treat as necessary based on Sx, evaluate renal function, pay close attention to differential diagnosis with sickle cell patients (may resemble sickle crisis).

Cause: immune response to foreign RBC antigens

Prevention: Avoid unnecessary transfusio

Cause: immune response to foreign antigens on WBCs and platelets

Prevention: avoid unnecessary transfusion, give leuko-reduced or irradiated blood where indicated

Cause: immunologically competent donor WBCs form antibodies to recipient antigens, mounting an immune response against the patient

Prevention: irradiate blood products prior to transfusion

Treatment: does not respond to most treatment regimens

Cause: recipient antibody to platelets (usually anti-P1A1)

Treatment: corticosteroids, plasmapheresis

Prevention: transfuse P1A1 negative platelets in the future

Cause: chronic transfusions leading to a build-up of excess iron in liver, heart, and endocrine glands

Prevention: keep transfusions to a minimum, transfuse with neocytes

Treatment: iron chelation therapy

Cause: massive transfusion leads to low levels of platelets and/or coagulation proteins that do not survive blood storage conditions

Prevention: monitor platelets during and after transfusion

Treatment: administer platelets

Delayed Transfusion Reactions Matchup

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Delayed Transfusion Reactions MatchupVersión en línea

por Sara Smith

Delayed HTR

Alloimmunization to RBC Antigens

Alloimmunization to HLA Antigen

Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD)

Post-Transfusion Purpura

Iron Overload/Transfusion Induced Hemosiderosis

Hematologic Events Associated with Transfusions