Leukocytic Disorders: Pathophysiology & Investigation

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Patho & labs

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Preechaya Wongkrajang

Tailandia

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AsterQuiz Leukocytic Disorders: Pathophysiology & InvestigationVersión en línea Patho & labs por Preechaya Wongkrajang 1 What primarily characterizes acute myeloid leukemia (AML) pathophysiology? a Increase in mature lymphocytes b Clonal proliferation of myeloid blasts with impaired maturation c Excess production of erythrocytes 2 On bone marrow exam, AML shows what key feature? a Hypercellularity with >20% myel blasts b Only mature granulocytes c Hypocellular marrow 3 A defining molecular feature of CML is what? a PAX5 rearrangement b NPM1 mutation c BCR-ABL1 fusion (Philadelphia chromosome) 4 Which mutation is commonly associated with polycythemia vera, essential thrombocythemia, and myelofibrosis? a BCR-ABL1 b CALR mutation only in ET c JAK2 V617F mutation 5 Which investigations best subclassify lymphoma? a Flow cytometry and immunohistochemistry for CD markers b Serum calcium levels c Karyotyping only 6 Multiple myeloma is defined by clonal plasma cells and what typical serum feature? a Decreased C-reactive protein b Monoclonal M protein (paraprotein) c Elevated TSH 7 Which condition is most commonly associated with lymphocytosis? a Brucellosis b Metabolic disorder c Allergic rhinitis 8 What is a typical finding in myeloproliferative neoplasms besides abnormal counts? a Pure erythrocytosis without leukocytes b Leukoerythroblastic picture (immature cells in peripheral smear) c Absence of blasts in smear 9 Auer rods are most characteristic of which leukemia type? a Chronic lymphocytic leukemia (CLL) b Acute lymphoblastic leukemia (ALL) c Acute myeloid leukemia (AML) 10 Prognostic assessment in leukemias and lymphoproliferative neoplasms often uses which markers? a Cytogenetics and molecular markers (e.g., FISH, PCR) b Albumin c LDH

AsterQuiz

Leukocytic Disorders: Pathophysiology & InvestigationVersión en línea

Patho & labs

por Preechaya Wongkrajang

What primarily characterizes acute myeloid leukemia (AML) pathophysiology?

Increase in mature lymphocytes

Clonal proliferation of myeloid blasts with impaired maturation

Excess production of erythrocytes

On bone marrow exam, AML shows what key feature?

Hypercellularity with >20% myel blasts

Only mature granulocytes

Hypocellular marrow

A defining molecular feature of CML is what?

PAX5 rearrangement

NPM1 mutation

BCR-ABL1 fusion (Philadelphia chromosome)

Which mutation is commonly associated with polycythemia vera, essential thrombocythemia, and myelofibrosis?

BCR-ABL1

CALR mutation only in ET

JAK2 V617F mutation

Which investigations best subclassify lymphoma?

Flow cytometry and immunohistochemistry for CD markers

Serum calcium levels

Karyotyping only

Multiple myeloma is defined by clonal plasma cells and what typical serum feature?

Decreased C-reactive protein

Monoclonal M protein (paraprotein)

Elevated TSH

Which condition is most commonly associated with lymphocytosis?

Brucellosis

Metabolic disorder

Allergic rhinitis

What is a typical finding in myeloproliferative neoplasms besides abnormal counts?

Pure erythrocytosis without leukocytes

Leukoerythroblastic picture (immature cells in peripheral smear)

Absence of blasts in smear

Auer rods are most characteristic of which leukemia type?

Chronic lymphocytic leukemia (CLL)

Acute lymphoblastic leukemia (ALL)

Acute myeloid leukemia (AML)

Prognostic assessment in leukemias and lymphoproliferative neoplasms often uses which markers?

Cytogenetics and molecular markers (e.g., FISH, PCR)

Albumin

LDH

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Leukocytic Disorders: Pathophysiology & Investigation

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AsterQuiz

Leukocytic Disorders: Pathophysiology & InvestigationVersión en línea

por Preechaya Wongkrajang

What primarily characterizes acute myeloid leukemia (AML) pathophysiology?

On bone marrow exam, AML shows what key feature?

A defining molecular feature of CML is what?

Which mutation is commonly associated with polycythemia vera, essential thrombocythemia, and myelofibrosis?

Which investigations best subclassify lymphoma?

Multiple myeloma is defined by clonal plasma cells and what typical serum feature?

Which condition is most commonly associated with lymphocytosis?

What is a typical finding in myeloproliferative neoplasms besides abnormal counts?

Auer rods are most characteristic of which leukemia type?

Prognostic assessment in leukemias and lymphoproliferative neoplasms often uses which markers?