GWAS in Physiology Challenge

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Test your GWAS basics and downstream concepts

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Carolina Arias

México

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GWAS in Physiology Challenge


Froggy Jumps GWAS in Physiology ChallengeVersión en línea Test your GWAS basics and downstream concepts por Carolina Arias 1 What does GWAS stand for and what does it primarily survey? a Gene-wide association studies; a few variants in a single group b Genome-wide association studies; thousands of genetic variants across many individuals c Genome-wide association studies; a single gene linked to a trait 2 In a Manhattan plot, what does a lead SNP represent? a The lowest P-value across the entire genome b A random SNP with no significance c The strongest significant signal at a genomic region 3 What is the main purpose of post-GWAS analyses? a To compute more P-values without biological context b To repeat the GWAS with bigger samples c To interpret associated SNPs and identify causal biology 4 Which method estimates global genetic correlation between traits? a Fine-mapping only b Cross-trait LD Score Regression (LDSC) c Mendelian Randomization (MR) 5 What is a polygenic score (PGS) used for? a Measuring a single gene’s effect b Determining ancestry directly from a single SNP c Predicting a trait or disease risk in individuals 6 Name a downstream approach that helps infer causation between traits. a Single-gene knockouts in animals b Genome editing c Mendelian randomization (MR) 7 What do eQTL and pQTL analyses relate to in GWAS? a Only environmental influences on traits b Only DNA sequence changes c Variant effects on gene expression or protein levels 8 Why is trans-ancestry GWAS important? a It restricts results to European ancestry b It improves fine-mapping and transferability of findings across populations c It only increases sample size without new loci 9 What is fine-mapping in GWAS used for? a Prioritizing likely causal variants and mapping to genes b Finding new genotyping technologies c Discarding non-significant SNPs without review 10 What does an endophenotype represent in physiology genetics? a A non-genetic environmental factor b An intermediate trait linking genetics to disease c The final disease diagnosis only

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GWAS in Physiology Challenge

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Froggy Jumps

GWAS in Physiology ChallengeVersión en línea

por Carolina Arias

What does GWAS stand for and what does it primarily survey?

In a Manhattan plot, what does a lead SNP represent?

What is the main purpose of post-GWAS analyses?

Which method estimates global genetic correlation between traits?

What is a polygenic score (PGS) used for?

Name a downstream approach that helps infer causation between traits.

What do eQTL and pQTL analyses relate to in GWAS?

Why is trans-ancestry GWAS important?

What is fine-mapping in GWAS used for?

What does an endophenotype represent in physiology genetics?