Capecitabine Dosing and Toxicity Quest

Froggy Jumps

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Capecitabine dosing, toxicity, and monitoring

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Lauren Hutton

Canadá

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Capecitabine Dosing and Toxicity Quest


Froggy Jumps Capecitabine Dosing and Toxicity QuestVersión en línea Capecitabine dosing, toxicity, and monitoring por Lauren Hutton 1 What are capecitabine's active metabolites? a FdUMP and FUTP b FdUMP and 5-FU) c 5-FU and dihydropyrimidinase 2 What is the most common non-hematologic toxicity of capecitabine? a Nephrotoxicity b Ophthalmic toxicity c Palmar-plantar erythrodysesthesia (hand-foot syndrome) 3 What is the antidote for capecitabine overdose? a Uridine triacetate b Vitamin K c N-acetylcysteine 4 Before starting capecitabine, which deficiency should be screened due to toxicity risk? a CYP2D6 deficiency b DPD deficiency c G6PD deficiency 5 What is the standard adult capecitabine dosing when used alone (monotherapy) per dose? a 1500 mg/m2 once daily for 21 days b 1250 mg/m2 twice daily for 14 days c 1000 mg/m2 daily for 7 days 6 How should dosing be adjusted for moderate renal impairment (CrCl 30-50 mL/min)? a Use 125% of the dose b Use 75% of the recommended dose with close monitoring c No adjustment needed 7 What baseline and ongoing monitoring is recommended for capecitabine? a Only renal function tests during treatment b Only CBC at baseline c CBC baseline and at each visit; renal and liver function tests 8 Which interaction significantly increases capecitabine toxicity and is contraindicated? a Amlodipine b Metformin c Sorivudine or related analogues (brivudine) 9 What is a practical management step for grade 2 hand-foot syndrome during therapy? a Increase dose to overcome resistance b Hold treatment until grade returns to ≤1 and use emollients c Continue at same dose without changes 10 Which precaution is emphasized before starting capecitabine related to infections and vaccines? a Start live vaccines during therapy b Screen for HIV c Screen for hepatitis B and manage accordingly

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Capecitabine Dosing and Toxicity Quest

Froggy Jumps

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Capecitabine Dosing and Toxicity QuestVersión en línea

por Lauren Hutton

What are capecitabine's active metabolites?

What is the most common non-hematologic toxicity of capecitabine?

What is the antidote for capecitabine overdose?

Before starting capecitabine, which deficiency should be screened due to toxicity risk?

What is the standard adult capecitabine dosing when used alone (monotherapy) per dose?

How should dosing be adjusted for moderate renal impairment (CrCl 30-50 mL/min)?

What baseline and ongoing monitoring is recommended for capecitabine?

Which interaction significantly increases capecitabine toxicity and is contraindicated?

What is a practical management step for grade 2 hand-foot syndrome during therapy?

Which precaution is emphasized before starting capecitabine related to infections and vaccines?