C difficile

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Jessica

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Completar Frases C difficileVersión en línea Fill in the blanks por Jessica 1 Healthy intestinal epithelial cells are initially intact . C . difficile germinate into toxin - producing vegetative cells in the colon . 24 hours after exposure : cells of the colon lining appear normal . 30 hours after exposure : Toxin A ( ) and Toxin B ( ) start damaging epithelial cells , causing and fluid . 36 hours after exposure : inflamed cells and die , leading to as spores exit the colon . influx occurs , forming a on the colon surface . 2 Both toxins Rho - family GTPases , disrupting the cytoskeleton . is less potent than , which is 100 ? 1000 times more potent . TcdA mainly acts as an , causing fluid and inflammation . TcdB acts as a , directly damaging cells . TcdA binds structures on gut epithelial cells , while TcdB binds receptors and has a cell tropism . requires cholesterol to form pores in cells , whereas is less cholesterol - dependent . 3 Binary toxin ( ) severity , recurrence , hospital stay , and mortality ; it acts of TcdA and TcdB . protects against phagocytosis . Flagella aid and adherence . enzymes help penetrate the mucus layer . Adhesins and facilitate to epithelial cells .