PBL 7.01 - HPO & Steroid MOA

Froggy Jumps

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HPO & Steroid MOA

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Helina

Reino Unido

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Froggy Jumps PBL 7.01 - HPO & Steroid MOAVersión en línea HPO & Steroid MOA por Helina 1 A 23-year-old woman presents with secondary amenorrhoea. Blood tests show low FSH and LH, and low oestradiol. MRI of the pituitary is normal. Which is the most likely site of pathology? a Hypothalamus b Pituitary gonadotroph cells c Ovary 2 Which hormone exerts positive feedback on the hypothalamic-pituitary axis to trigger the mid-cycle LH surge? a Progesterone b Oestradiol c Inhibin B 3 A 30-year-old woman undergoes IVF. To prevent premature LH surge, she is given a drug that acts as a GnRH antagonist. What is its primary action? a Increases pituitary sensitivity to GnRH b Directly stimulates LH release c Suppresses pituitary gonadotropin secretion 4 Which ovarian hormone specifically inhibits FSH secretion without affecting LH? a Oestradiol b Progesterone c Inhibin 5 In the early follicular phase, which hormone is primarily responsible for recruiting a dominant follicle? a LH b FSH c Oestradiol 6 Which is the primary mechanism of action of steroid hormones such as oestrogen and cortisol? a Activation of G-protein coupled receptors b Opening of ligand-gated ion channels c Binding to intracellular receptors to regulate transcription 7 Synthetic glucocorticoids such as prednisolone exert anti-inflammatory effects through which key mechanism? a Direct killing of immune cells b Inhibition of phospholipase A2 and cytokine transcription c Activation of adrenergic receptors 8 A 50-year-old woman is prescribed tamoxifen for breast cancer. What is its mechanism of action? a Aromatase inhibitor b Oestrogen receptor agonist c Selective oestrogen receptor modulator (SERM) 9 Mifepristone is used in medical termination of pregnancy. What is its primary mechanism? a Inhibits GnRH secretion b Blocks progesterone receptors c Inhibits implantation by damaging endometrium 10 Which feature distinguishes steroid hormone action from peptide hormone action? a Binding to cell-surface receptors b Alteration of gene transcription after receptor binding c Storage in secretory vesicles before release

Froggy Jumps

PBL 7.01 - HPO & Steroid MOAVersión en línea

HPO & Steroid MOA

por Helina

A 23-year-old woman presents with secondary amenorrhoea. Blood tests show low FSH and LH, and low oestradiol. MRI of the pituitary is normal. Which is the most likely site of pathology?

Hypothalamus

Pituitary gonadotroph cells

Ovary

Which hormone exerts positive feedback on the hypothalamic-pituitary axis to trigger the mid-cycle LH surge?

Progesterone

Oestradiol

Inhibin B

A 30-year-old woman undergoes IVF. To prevent premature LH surge, she is given a drug that acts as a GnRH antagonist. What is its primary action?

Increases pituitary sensitivity to GnRH

Directly stimulates LH release

Suppresses pituitary gonadotropin secretion

Which ovarian hormone specifically inhibits FSH secretion without affecting LH?

Oestradiol

Progesterone

Inhibin

In the early follicular phase, which hormone is primarily responsible for recruiting a dominant follicle?

FSH

Oestradiol

Which is the primary mechanism of action of steroid hormones such as oestrogen and cortisol?

Activation of G-protein coupled receptors

Opening of ligand-gated ion channels

Binding to intracellular receptors to regulate transcription

Synthetic glucocorticoids such as prednisolone exert anti-inflammatory effects through which key mechanism?

Direct killing of immune cells

Inhibition of phospholipase A2 and cytokine transcription

Activation of adrenergic receptors

A 50-year-old woman is prescribed tamoxifen for breast cancer. What is its mechanism of action?

Aromatase inhibitor

Oestrogen receptor agonist

Selective oestrogen receptor modulator (SERM)

Mifepristone is used in medical termination of pregnancy. What is its primary mechanism?

Inhibits GnRH secretion

Blocks progesterone receptors

Inhibits implantation by damaging endometrium

Which feature distinguishes steroid hormone action from peptide hormone action?

Binding to cell-surface receptors

Alteration of gene transcription after receptor binding

Storage in secretory vesicles before release

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PBL 7.01 - HPO & Steroid MOA

Froggy Jumps

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PBL 7.01 - HPO & Steroid MOAVersión en línea

por Helina

A 23-year-old woman presents with secondary amenorrhoea. Blood tests show low FSH and LH, and low oestradiol. MRI of the pituitary is normal. Which is the most likely site of pathology?

Which hormone exerts positive feedback on the hypothalamic-pituitary axis to trigger the mid-cycle LH surge?

A 30-year-old woman undergoes IVF. To prevent premature LH surge, she is given a drug that acts as a GnRH antagonist. What is its primary action?

Which ovarian hormone specifically inhibits FSH secretion without affecting LH?

In the early follicular phase, which hormone is primarily responsible for recruiting a dominant follicle?

Which is the primary mechanism of action of steroid hormones such as oestrogen and cortisol?

Synthetic glucocorticoids such as prednisolone exert anti-inflammatory effects through which key mechanism?

A 50-year-old woman is prescribed tamoxifen for breast cancer. What is its mechanism of action?

Mifepristone is used in medical termination of pregnancy. What is its primary mechanism?

Which feature distinguishes steroid hormone action from peptide hormone action?

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