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Chapter 25 Cholinergic Drugs

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Chapter 25 Cholinergic Drugs

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Chapter 25 Cholinergic Drugs
 

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Chapter 25 Cholinergic DrugsVersión en línea

test your knowledge

por Breanna Spears
1

muscarinic nicotinic

There are two types of repetors in the parasympathetic nervous branch : receptors ( which stimulates smooth muscle ) and receptors ( which stimulates skeletal muscle ) .

2

Cholinergic parasympathomimetic synergistic adrenergic acetylcholinesterase

drugs mimic the activity of the parasympathetic nervous system . They are also called drug s

3

ACh AChE Acetylcholinesterase

( ) is an enzyme that can inactivate the neurotransmitter , thereby preventing the nerve synapse from continuing the nerve impulse .

4

acetylcholinesterse norepinephrine Acetylcholine ACh

( ) is the neurotransmission substance that carries nerve impulses across the parasympathetic branch of the autonomic nervous system .

5

dementia Alzheimer myasthenia gravis lewy body colon

This interruption in neurotransmission can diminish cognitive function , which is seen in illnesses such as disease .

6

anticolontise drugs cholinergic anticholinesterase dopamine inhibitors acetylcholinsterase

Drugs that inhibit the enzyme AChE are called or .

7

cardiac reproductive respiratory elimination vision circulatory acting direct cholinergics digestion

Drugs acting on the sympathetic nervous system more prominently impact the , , or systems . Cholinergic drugs that act on the parasympathetic nervous system more prominently impact , , and the system . Drugs like ACh are called - .

8

stimulants muscle ACh cholinergics indirect anticholinesterase acting AChe

Cholinergic drugs that prolong the activity of by inhibiting the release of are called - or . This occurs when there's a lack of ACh being released at the nerve endings of the PN S

9

glaucoma gravis immunotherapy myasthenia

An example of indirect action is the use of cholinergic drugs to treat , a disease that involves rapid fatigue of skeletal muscles . Primary treatment of this disease is accomplished with .

10

direct indirect-acting cholinergics micturition urinary retention cholinergics neurogenic bladder acting miosis

Drugs like ACh are called - . An example of cholinergic influence is on the act of ( voiding of urine ) .

11

involuntary relaxing parasympathetic involuntary acting cholinergic Urinary retention indirect-acting cholinergics volunty fluid retention retention urinary constricting contraction direct

Micturition is both a and an act . The branch of the autonomic nervous system party controls the ( ) process of micturition by the detrusor muscle and the bladder sphincter . results when micturition is impaired . Treatment of with - drugs causes of the bladder smooth muscles and passage of urine .

12

miosis indirect acting anticholinesterase muscle stimulant cholinergic direct-acting cholinergic micturition mitosis glaucoma

Treatment of with an - drugs produces ( constriction of the iris ) .

13

Dopamine cholinergic Acytylcholinesterase Acetylcholine Norepinephrine

Which of the following is the substance responsible for transmission of nerve impulses across the parasympathetic nervous system ?

14

abdominal cramping Cardiac arrythmias retention gravis gastroinintestinal issues Myasthenia Urinary Neurogenic fluid retention relaxed

Major uses of the cholinergic drugs are in the treatment of the following :
, bladder , and .

15

tissue perfusion diarrhea myasthenia gravis urinary retention muscle cardiac weakness arrythmias flushing salivation Nausea respiratory distress dizziness

General adverse reactions include the following :
, , abdominal cramping , , of the skin , , and .

16

peptic coronary GI hyperthyroidism genitourinary atropine glaucoma Bethanol corneal hypersensitivity iritis asthma

These drugs are contraindicated in clients with known to the drugs , , ulcers disease , artery disease , and . is contraindicated in those with mechanical obstruction of the or tracts . Clients with secondary , , abrasion , or any actue inflammatory disease of the eye should not use the ophthalamic cholinergic preparations .

17

tachycardia lactation C pregnancy D megacolon coronary cardiac hypotension bradycardia hypertension arrhythmias E

These drugs are used cautiously in clients with , epilepsy , , , recent occlusion , and . The safety of the drugs have NOT been established for use during ( pregnancy category ) , , or children

18

synergistic anticholinergic Bethanechol agonizes antagonizes Zyban atropine eliminator Pyridostigmine acetylcholinesterase anticholinergic antidote amplifies cholinergic

When drugs are administered with the other cholinergics , there is a ( the effect is greater than that of each of the two drugs separately ) effect of the drugs and greater risk for toxicity . Concurrent use of more than one drug the effects of cholinergic drugs . Because drugs can have this additive effect , is the drug used as an for overdose of cholinergic drugs .

19

constipation Cholinergic weakness muscle corticosteriods nausea Zyban diarrhea atropine dry mouth salivation

crisis ( cholinergic drug toxicity ) symptoms include severe abdominal cramping , , excessive , , rigidity and spasm , and clenching of the jaw . In case of drug overdose , an antidote such as is administered .

20

presence between gravis before increased absence response myasthenia decreased client's

For a client with , you have to assess the client for the or of the symptoms before each drug dose ( extreme fatigue , drooping eyelids , muscle weakness , inability to chew and swallow , etc ) . Carry out these assessments drug doses as well as immediately drug administered . Assessment is important because the dosage ferequently is or early in therapy , depending on the .

21

subcutaneous IV buccal 20-30 15 5 90 oral 30 30-60

Voiding usually occurs in - min after drug administration and - min after administration

22

1-2 3-4 release myasthenia Sustained time-released 2 gravis 4

Oral drug administration is typically the route used to manage symptoms of . Clients with severe symptoms of the disease require the drug every - hr , even during the night . - tablets are available that alow less frequent dosing and help the client have longer undisturbed periods during the night .

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