Outline the in vitro coagulation cascades

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intrinsic, extrinsic, and common pathways

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Gawain

Estados Unidos

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Completar Frases Outline the in vitro coagulation cascadesVersión en línea intrinsic, extrinsic, and common pathways por Gawain 1 Xa X vitro XIa XIIa IXa vivo IXa XIIa XII XIa XII XI VIIIa IX aPTT Xa in in Intrinsic Pathway ( Contact Activation Pathway ) Triggered by exposure to negatively charged surfaces Requires phospholipid from platelet membrane Factors involved : Factor ? Activated by contact with foreign surfaces activates Factor ? activates Factor ? + cofactor ( activated by thrombin ) form tenase complex Tenase complex activates Factor ? activates common pathway * Factor is not important ( real - life clotting ) , but it is critical ( lab tests like ) 2 Time VIIa PT TF Prothrombin Xa IXa IX Xa X TF VII Extrinsic Pathway ( Tissue Factor Pathway ) Triggered by tissue injury and exposure of tissue factor ( Factor III ) Phospholipid source = damaged endothelium ( tissue factor ) Factors involved : Tissue Factor ( III ) binds with Factor ? ? VIIa complex activates Factor ? ? common pathway ? VIIa complex also activates Factor ? Initiates coagulation quickly and bypasses the contact phase Tested by ( ) 3 V Thrombin II IIa Xa Prothrombin Va VIII Fibrin Fibrinogen Thrombin XIIIa XIII Common Pathway Starts with activation of Factor X ? Xa Factors involved : + cofactor = Prothrombinase complex Converts ( ) ? ( ) : Converts ? monomers Activates Factor ? ? crosslinks fibrin = stable clot Activates Factors and ( positive feedback ) 4 X tissue factor VII IX XII III XI V VIII II State what factors belong to the intrinsic , extrinsic , and common pathways Intrinsic / Contact System Prekallikrein ( PK ) , high - molecular - weight kininogen ( HK ) , , , , and Extrinsic and ( ) Common pathway , , , I 5 BK PK high XII BK kininogen HK Bradykinin molecular weight Prekallikrein Describe contact activation and list the substances involved Contact activation pathway : there is a substance in the blood initiating procoagulant molecules . Activated by negatively charged surfaces ( i . e Endothelial cells , leukocytes , bacteria , thrombocytes ) ( ) , - - ( ) , activated by negatively charged substances ? production of ( ) binds to cell membrane receptors ? starts signaling pathways ? increases inflammatory processes Does not contribute to normal clot formation in vivo but does contribute to inflammation , blood pressure regulation and fibrinolysi s

Completar Frases

Outline the in vitro coagulation cascadesVersión en línea

intrinsic, extrinsic, and common pathways

Xa X vitro XIa XIIa IXa vivo IXa XIIa XII XIa XII XI VIIIa IX aPTT Xa in in

Intrinsic Pathway ( Contact Activation Pathway )
Triggered by exposure to negatively charged surfaces
Requires phospholipid from platelet membrane
Factors involved :
Factor ?
Activated by contact with foreign surfaces
activates Factor ?
activates Factor ?
+ cofactor ( activated by thrombin ) form tenase complex
Tenase complex activates Factor ?
activates common pathway
* Factor is not important ( real - life clotting ) , but it is critical ( lab tests like )

Time VIIa PT TF Prothrombin Xa IXa IX Xa X TF VII

Extrinsic Pathway ( Tissue Factor Pathway )
Triggered by tissue injury and exposure of tissue factor ( Factor III )
Phospholipid source = damaged endothelium ( tissue factor )
Factors involved :
Tissue Factor ( III ) binds with Factor ?
? VIIa complex activates Factor ?
? common pathway
? VIIa complex also activates Factor ?
Initiates coagulation quickly and bypasses the contact phase
Tested by ( )

V Thrombin II IIa Xa Prothrombin Va VIII Fibrin Fibrinogen Thrombin XIIIa XIII

Common Pathway
Starts with activation of Factor X ? Xa
Factors involved :
+ cofactor = Prothrombinase complex
Converts ( ) ? ( )
:
Converts ? monomers
Activates Factor ? ? crosslinks fibrin = stable clot
Activates Factors and ( positive feedback )

X tissue factor VII IX XII III XI V VIII II

State what factors belong to the intrinsic , extrinsic , and common pathways
Intrinsic / Contact System
Prekallikrein ( PK ) , high - molecular - weight kininogen ( HK ) , , , , and
Extrinsic
and ( )
Common pathway
, , , I

BK PK high XII BK kininogen HK Bradykinin molecular weight Prekallikrein

Describe contact activation and list the substances involved
Contact activation pathway : there is a substance in the blood initiating procoagulant molecules .
Activated by negatively charged surfaces ( i . e Endothelial cells , leukocytes , bacteria , thrombocytes )
( ) , - - ( ) , activated by negatively charged substances ? production of ( )
binds to cell membrane receptors ? starts signaling pathways ? increases inflammatory processes
Does not contribute to normal clot formation in vivo but does contribute to inflammation , blood pressure regulation and fibrinolysi s

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Outline the in vitro coagulation cascades

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Outline the in vitro coagulation cascadesVersión en línea

por Gawain

Xa X vitro XIa XIIa IXa vivo IXa XIIa XII XIa XII XI VIIIa IX aPTT Xa in in

Time VIIa PT TF Prothrombin Xa IXa IX Xa X TF VII

V Thrombin II IIa Xa Prothrombin Va VIII Fibrin Fibrinogen Thrombin XIIIa XIII

X tissue factor VII IX XII III XI V VIII II

BK PK high XII BK kininogen HK Bradykinin molecular weight Prekallikrein

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