Relacionar Columnas Compounding weeks 1-13Versión en línea GANG U NEED TO DO GOOD IN THEORY OR ELSE YOU WILL FAIL por Audree Dulnuan 1 When did WHMIS came into effect 2 Caution 3 WHMIS 4 GHS (WHMIS 2015) 5 What does GHS (WHMIS 2015) do? 6 HPR 7 CPR 8 Upside down triangle border 9 What is HPA regulates? 10 Extreme danger 11 Danger 12 HPA 13 Octagon border 14 What are key elements of WHMIS Means that the contents of the container are dangerous Workplace Hazardous Materials Information System Means the injury will most likely be temporary, but death may occur w extreme exposure Hazardous products regulations Globally harmonized system October 31, 1988 (The first whmis) Means the products may cause temporary or permanent injury or death. Controlled product regulations Hazardous Products Act Set labelling & MSDS requirements for suppliers. Means that the container itself is dangerous Means exposure w even small amounts of the product may cause temporary or permanent injury or death. Hazard classification, cautionary labelling of containers, provision of MSDSs, worker education programs Defines & classifies the hazards through labels & safety data sheets. 1 2 3 4 5 6 7 8 9 10 Flame (flammable) Biohazardous infectious materials Hazards to the environment Health hazard Flame over circle (oxidizing) Skull & crossbones (acute toxicity) Exclamation mark (health hazards) Corrosion Exploding bomb (explosive) Gas cylinder (gass under pressure) 1 Occlusive 2 Mucosal surfaces 3 Ointment 4 Skin folds 5 Dry, scaly skin conditions 6 Inflamed skin 7 Wet/oozy skin conditions 8 Lotion 9 Emollient 10 Oleaginous 11 Hariy areas 12 Stratum corneum 13 Gel 14 Palms & soles 15 Cream 16 Humectant 17 Cracks & sores Non-irritating formulations to avoid irritating eroded surfaces Substance that causes water retention Usually considered thicker than a solution & more likely to contain oil as well as water or alcohol Substance that promotes retention of water in the skin by forming a barrier that prevents moisture in the skin Agent which softens the skin or soothes irritation on skin creams, lotions, & drying pastes Aqueous or alcoholic monophasic semisolid emulsion Thicker than a lotion 70% water & 30% grease, a 50/50 emulsion of oil & water (30 days exp.) Semi-solid, water-free (80% oil), 6 months exp. Ointment or cream may be preffered ointments & oils are appropriate Bricks & mortar allow substances to pass rich in, covered w, producing oil, oily/greasy Lotion, solution, gel or foam Use a cream or a lotion Wet compresses & soaks followed by creams/ointments Bland preparations; avoid alcohol & acidic preparations. 1 Pharmacy manager/pharmacy department head 2 Non-regulated personnel 3 Non-sterile compounding supervisor 4 What does centennial college use as an alternative w MFR/CR 5 Regulated Pharmacy personel 6 MFR-Master Formulation Records 7 What levigating agent is used for cream? 8 Compounding Record-CR 9 What levigating agent is used for ointment? Recipe, list of instructions, ingredient list/preparation instructions Oversees the entire pharmacy MFS-Master formula sheet Glycerin Can only perform assigned compounding tasks under supervision after proper training Responsible & accountable for compounding & patient care Mineral oil Specifically manages & supervises compounding activities Patient-specific preparation, lot, exp, weights, names, quality control 1 Level C 2 Simple 3 Group 3 4 Level B 5 Risk assessment 6 Complex 7 Group 1 8 Tween 20 & Tween 80 9 Group 2 10 Methylparaben & propylparaben 11 Moderate 12 Level A 13 NIOSH separate space when compounding simple & complex. anti-fungal preservative Requires special training, environment, facilities, equipment. Emulsifying agents Requires special calculations/procedures Preparing using USP monograph-specified ingredients, procedures, equipment, stability/BUD and following manufacturer directions Non-antineoplastic drugs, meets one or more NIOSH hazardous drugs Non-antineoplastic drugs, pose reproductive risk Dedicated room & negative pressure, C-PEC National Institute for Occupational Safety & Health Dedicated room, complex preparations, or small quantities need more training w no interruptions. Must be reviewed every 12 months. Antineoplastic drugs (cytotoxic drugs) 1 Relative density less than 1 2 Solutions 3 Eutectic Mixture 4 Syrups 5 Relative density greater than 1 6 Aromatic waters 7 Menthol, crystals 8 Density 9 Urea 10 Mixing liquids techniques 11 Relative density is exactly 1 12 Compounding Techniques for Oral Elixirs 13 Elixirs 14 Suspension 15 Specific gravity 16 Specific gravity formula 17 Menthol & camphor 18 Density formula The density is the same as water Needs to be dissolved in alcohol, anti-pruritic Clear liquid preparations Density of substance/density of water Water component is added to the alcohol component Solutions that are sweetened & alcohol-based (5%-40%) Ratio of a substance's weight to the weight of same volume of water Higher density liquid should be added to lower density liquids while constantly stirring. Quantity of mass & volume, absolute term, P The substance would sink g/ml mass/volume Anti-pruritic, eutectic mixture Liquids that contain ingredients, both active & inert, not soluble in the vehicle A mixture of 2 or more components that do not mix together forms into a liquid. Substance would float Clear saturated aqueous solutions of volitile oils or aromatic substances Use to improve the taste some foul or bitter tasting active ingredients Dissolved in boiling water, emollient agent 1 Alcohol in 6yrs-12yrs old 2 Chlorhexidine 3 Sodium benzoate 4 Alcohol in 12yrs & up 5 OTC prodcuts that contains alcohol 6 99% Alcohol 7 Lower concentration of alcohol 8 Why is 70% most effective? 9 Sucrose 10 Methylcellulose 60%-90% alcohol is effective Less than 6yrs old should be alcohol-free. Suspending agent, used to thicken liquid to prevent it from settling to the bottom quickly Common sugar, added to medicines as a sweetening agent Antiseptic, effective against gram-negative/positive bacteria, yeast, fungi Max alcohol 5% anti-fungal, added to oral liquids to prevent fungal growth Antiseptic, vehicle, diluent 10 % max alcohol 50% of alcohol and lower may be less effective & requires more time 1 Features of C-SEC 2 Methadone for pain 3 C-SEC 4 Take Home doses 5 Methadone labelling 6 PPE-2 pairs of chemotherapy gloves 7 Waste management 8 True discrepancies (shortage/loss) 9 PPE mask N95 10 Effects of methadone 11 Tetracycline 12 C-PEC 13 What is the appropirate measuring device for Methadone 14 Methadone 15 Maintenance of C-PEC 16 Auxillary label for methadone 17 Midazolam Syrup (Benzodiazepine) Product name, total dose, drug has been diluted, drink the entire contents of bottle, date of ingestion Containment secondary engineering control, the room which C-PEC is placed for compounding Level C Keep in refrigerator & May be fatal to child or adult Should be inspected every 6 months; all reusable equipment should be deactivated & cleaned. Equipment should not be removed. Measured using devices of 0.1 mL increments, only drugs authorized for drug addiction, effective 80% 12 air changes per hour, negative pressure -2.5 Pa, no windows Dispensette: 0.5-5 mL, 0.5% accurate It's important to filter after preparation; it may cause a fever. patient signs: doses will be kept locked, will not lend/sell, will take doses properly, return empty bottles, have regular urine tests. when deactivating/decontaminating C-PEC, spills, cleaning Relieve anxiety & produce sleepiness before surgery, produce amnesia, treats status epilepticus Should be changed 3.5 hours of continuous work after each removal, if contamination has occurred. Must be reported externally to Health Canada within 10 days Containment primary engineering control. Ventilated device to minimize exposure of workers & the environment Pharmaceutical products that are expired or no longer usable are considered pharmaceutical waste. Spills should complete an event report. Only MD can prescribe, for use in non-cancer pain, 6-8 hrs of pain relief Long-acting opioids act slower in the body; effects may last 24-36 hrs a day, can take weeks.
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