Relacionar Columnas pathophysiologyVersión en línea inflammation, tissue repair, wound healing por angelina 1 immune response 2 functio laesa 3 rubor 4 dolor 5 inflammation reaction 6 tumor 7 tissue repair & wound healing 8 calor swelling loss of function heat pain vascular & cellular response innate & adaptive redness regeneration & replacement 1 prostagliandins action 2 histamine action 3 cytokines source 4 complement protein action 5 complement proteins source 6 leukotrienes source 7 leukotrienes action 8 prostaglandins source 9 cytokines action 10 histamine source coordinate immune response, promote inflamation pain, fever, vasodialation attract immune cells, destrroy pathogens damaged tissues, leukocytes vasodialation & increased vascular permeability recruit leukocytes, bronchoconstriction macrophages, t cells leukocytes, mast cells mast cells, basophils liver, plamsa proteins 1 serosanguineous 2 innate immunity 3 serous exudate 4 assessing wound exudate 5 hemorrhagic exudates 6 adaptive 7 purulent or suppuratice exudate Contain pus; composed of degraded white blood cells, proteins, and tissue debris 1.color 2. amount 3. smell 4. culture/swab if any of the above are abnormal Specific, learned response involving lymphocytes and memory. bright red watery damage to blood vessels or when there is significant leakage of red cells from the capillaries light pink Nonspecific, immediate defense (e.g., neutrophils, macrophages, barriers). clear/ pale yellow Result from plasma entering the inflammatory site 1 chronic inflammation ex 2 granulomatous inflammation ex 3 stable body cells 4 healing primary 5 acute inflamation ex 6 acute inflammation define 7 Chronic inflamation define 8 permanant body cells 9 granulomatous inflammation define 10 healing secondary 11 labile body cells a distinctive form of chronic inflammation characterized by the formation of granulomas — small, organized collections of macrophages Continue to divide and replicate throughout life, replacing cells that are continually being destroyed. Ex. skin cells, GI intestinal lining A recurrent or progressive acute inflammatory process or a low-grade smoldering response that fails to evoke an acute response Cannot undergo mitotic division Ex. neurons and cardiac cells relatively short duration; nonspecific early response to injury Aimed primarily at removing the injurious agent and limiting tissue damage splinter, tuberculosis flu great loss of tissue with contamination, wounds heal from the bottom up. Normally stop dividing when growth ceases but can regenerate if injured. Ex. hepatocytes (liver cells), lymphocytes (a type of white blood cell) small, clean wound with appoximated edges copd 1 inflammatory phase 2 maturational phase 3 proliferative phase 1-6 days Goals to stop bleeding, remove debris and prepare for healing via platelet aggregation and vasodilation 4-24 days Focuses on tissue regeneration and building new structures Focuses on tissue regeneration and building new structures fibroblast 1 year The final phase, focused on strengthening and remodeling of the repaired tissue. 1 transplant rejection acute 2 Immunodeficiency Disorders primary 3 Rheumatoid arthritis 4 type 1 diabetes 5 SLE "lupus" 6 transplant rejection chronic 7 type1 hypersensitivity 8 type 3 hypersensitivity 9 Immunodeficiency Disorders secondary 10 Transplant Rejection hyperacute 11 graves disease 12 Graft Versus Host Disease 13 type 2 hypersensitivity 14 type 4 hypersensitivity tachycardia, heat intolerance, weight loss •Fever •Organ dysfunction (e.g., rising creatinine in kidney transplant) •Frequent infections •Opportunistic infections (Pneumocystis, Candida) •Weight loss •Fever, night sweats •Low CD4 count •Itching, urticaria (hives) •Rhinorrhea, sneezing (hay fever) •Bronchoconstriction, wheezing (asthma) •Hypotension, airway swelling (anaphylaxis) joint swelling, morning stiffness •Skin: rash, peeling •Liver: jaundice, elevated LFTs •GI: diarrhea, abdominal pain polyuria, polydipsia, weight loss fatigue, joint pain, butterfly rash •Hemolysis (jaundice, pallor, fatigue) •Fever/chills during transfusion reaction •Newborn hemolytic disease (Rh incompatibility) •Joint pain •Rash •Proteinuria/kidney involvement •Vasculitis •Features of SLE (fatigue, butterfly rash) •Organ turns mottled, cyanotic •Immediate graft failure •Redness, itching, blistering (contact dermatitis) •Induration at TB skin test site •Progressive organ failure •Hypertension (kidney) •Shortness of breath (lung) •Recurrent infections •Severe infections from common organisms •Failure to thrive (in infants)
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