Quiz: World Antimicrobial Awareness Week 2025

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Antibiotic - MOA & AST

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Microbiology GMC Aurangabad

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Quiz: World Antimicrobial Awareness Week 2025


Quiz: World Antimicrobial Awareness Week 2025Versión en línea Antibiotic - MOA & AST por Microbiology GMC Aurangabad 1 Which of the following antibiotics inhibits bacterial cell wall synthesis? a Gentamicin b Ciprofloxacin c Vancomycin d Tetracycline 2 The main mechanism of resistance to β-lactam antibiotics in Gram-negative bacteria is: a Altered ribosomal binding site b Production of β-lactamase enzyme c Decreased permeability to the drug d Increased efflux pump activity 3 Which class of antibiotics inhibits protein synthesis by binding to the 30S ribosomal subunit? a Aminoglycosides b Macrolides c Chloramphenicol d Lincosamides 4 Which of the following is NOT a β-lactam antibiotic? a Imipenem b Cefoxitin c Aztreonam d Linezolid 5 Methicillin resistance in Staphylococcus aureus is due to: a β-lactamase production b Mutation in DNA gyrase c Altered penicillin-binding protein (PBP2a) d Increased efflux pump activity 6 Resistance to aminoglycosides is most commonly caused by: a Altered ribosomal target site b Enzymatic modification (acetylation, phosphorylation, adenylation) c Decreased permeability d Overproduction of target enzymes 7 Which of the following antibiotics acts by inhibiting folate synthesis? a Sulfonamides b Rifampicin c Chloramphenicol d Streptomycin 8 Which of the following is the mechanism of resistance to macrolides? a Methylation of 23S rRNA binding site b β-lactamase production c Altered DNA gyrase d Mutation in porin channels 9 Fluoroquinolones act by inhibiting: a DNA polymerase b RNA polymerase c DNA gyrase and topoisomerase IV d Peptidoglycan transpeptidase 10 Which of the following is a glycopeptide antibiotic? a Linezolid b Polymyxin B c Vancomycin d Meropenem 11 Resistance to fluoroquinolones may develop due to: a Methylation of rRNA b Alterations in DNA gyrase/topoisomerase genes c β-lactamase production d Increased cell wall permeability 12 Extended Spectrum β-Lactamases (ESBLs) confer resistance to: a Penicillin only b Carbapenems c Cephalosporins and monobactams d Aminoglycosides 13 The mechanism of resistance to tetracyclines commonly involves: a Enzyme degradation b Ribosomal methylation c Efflux pump-mediated drug removal d Altered DNA replication enzymes 14 Which of the following acts on the bacterial cell membrane? a Polymyxins b Chloramphenicol c Linezolid d Rifampicin 15 Vancomycin resistance in Enterococcus species is mainly due to: a β-lactamase production b Substitution of D-Ala-D-Lac in peptidoglycan precursors c Mutation in ribosomal RNA d Enzymatic drug degradation 16 Which AST method provides a quantitative MIC value along with a gradient diffusion? a Disk diffusion b Agar dilution c E-test d Modified Hodge test 17 The standard medium used for routine disk diffusion testing is: a Müller-Hinton agar b Nutrient agar c MacConkey agar d Blood agar 18 MIC is defined as: a Max inhibitory concentration b Minimum inhibitory concentration c Mild inhibitory concentration d Multiplex inhibitory concentration 19 Primary goal of AMSP is to: a Increase antibiotic use b Minimize laboratory workload c Optimize antimicrobial use and reduce resistance d Promote new drug development 20 Which of the following is a core strategy in AMSP? a Prospective audit with feedback b Random antibiotic restrictions c Increase antibiotic formulary d All of the above 21 Defined Daily Dose (DDD) is the unit used to measure: a Potency b Hospital consumption trends c Resistance rate d Patient compliance 22 Antibiotic cycling refers to: a Rotating antibiotics periodically to reduce resistance b Prescribing exercise with antibiotics c Using two antibiotics simultaneously d De-escalation 23 Which is an example of a restricted antibiotic policy? a Open access to meropenem b Pharmacy substitution allowed freely c Carbapenems require ID specialist approval d Empirical use of colistin 24 Which indicator best assesses success of AMSP? a Bed occupancy b Reduction in antibiotic consumption and resistance pattern c Staff strength d Increase in mortality 25 De-escalation therapy means: a Stopping all antibiotics b Switching from broad to narrow spectrum based on culture c Giving multiple drugs d Increasing dose 26 Which of the following is a supplemental AMSP strategy? a Prior authorization b Dose optimization based on PK/PD c Education and guidelines d Prospective audit 27 Post-prescription review is ideally done at: a 6 hours b 24 hours c 48-72 hours d 7 days 28 D-zone test is performed to detect resistance in: a MRSA b Vancomycin resistance in Enterococci c Inducible clindamycin resistance in Staphylococcus spp d ESBL producers 29 Zone of inhibition in Kirby–Bauer disk diffusion test is influenced by all except: a Agar depth b Inoculum density c Incubation time d pH of sample 30 Which professional must be mandatory in AMSP core team? a Dermatologist b Microbiologist c Physiotherapist d Radiologist

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Quiz: World Antimicrobial Awareness Week 2025Versión en línea

por Microbiology GMC Aurangabad

Which of the following antibiotics inhibits bacterial cell wall synthesis?

The main mechanism of resistance to β-lactam antibiotics in Gram-negative bacteria is:

Which class of antibiotics inhibits protein synthesis by binding to the 30S ribosomal subunit?

Which of the following is NOT a β-lactam antibiotic?

Methicillin resistance in Staphylococcus aureus is due to:

Resistance to aminoglycosides is most commonly caused by:

Which of the following antibiotics acts by inhibiting folate synthesis?

Which of the following is the mechanism of resistance to macrolides?

Fluoroquinolones act by inhibiting:

Which of the following is a glycopeptide antibiotic?

Resistance to fluoroquinolones may develop due to:

Extended Spectrum β-Lactamases (ESBLs) confer resistance to:

The mechanism of resistance to tetracyclines commonly involves:

Which of the following acts on the bacterial cell membrane?

Vancomycin resistance in Enterococcus species is mainly due to:

Which AST method provides a quantitative MIC value along with a gradient diffusion?

The standard medium used for routine disk diffusion testing is:

MIC is defined as:

Primary goal of AMSP is to:

Which of the following is a core strategy in AMSP?

Defined Daily Dose (DDD) is the unit used to measure:

Antibiotic cycling refers to:

Which is an example of a restricted antibiotic policy?

Which indicator best assesses success of AMSP?

De-escalation therapy means:

Which of the following is a supplemental AMSP strategy?

Post-prescription review is ideally done at:

D-zone test is performed to detect resistance in:

Zone of inhibition in Kirby–Bauer disk diffusion test is influenced by all except:

Which professional must be mandatory in AMSP core team?