PGx Week 11 Practice Quiz: Methods of PGx Testing

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Methods of sample collection, DNA sequencing and target variant analysis, germline polymorphism and somatic mutations

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Sophia

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PGx Week 11 Practice Quiz: Methods of PGx TestingVersión en línea Methods of sample collection, DNA sequencing and target variant analysis, germline polymorphism and somatic mutations por Sophia 1 Which of the following accurately describe a germline polymorphism? a a polymorphism that is is limited to DNA in a single tissue b a polymorphism that is inherited c a polymorphism that cannot be passed to offspring d a polymorphism that occurs after conception 2 T/F: Polymorphisms affecting CYP enzymes are somatic mutations. a True b False 3 Which of the following cells lack a nucleus, and therefore cannot be used as a DNA source to test for germline polymorphisms? Select all that apply. Choose one or more answers a red blood cells b platelets c white blood cells d epithelial cells 4 Patient RA has been taking tramadol for acute pain management, but states he has not been experiencing adequate pain relief. Which of the following testing analysis methods would you select to evaluate if RA's lack of analgesic effect is attributed to a CYP2D6 polymorphism? a whole genome sequencing b whole exome sequencing c target variant analysis 5 Which of the following is an advantage of using buccal swabs as a DNA sample collection? a results in higher DNA yields than peripheral blood collection b noninvasive and easy to perform c low risk of nonhuman DNA contamination 6 T/F: Various ethnic groups will have different allele frequencies for a given gene. a True b False

PGx Week 11 Practice Quiz: Methods of PGx TestingVersión en línea

Methods of sample collection, DNA sequencing and target variant analysis, germline polymorphism and somatic mutations

por Sophia

Which of the following accurately describe a germline polymorphism?

a polymorphism that is is limited to DNA in a single tissue

a polymorphism that is inherited

a polymorphism that cannot be passed to offspring

a polymorphism that occurs after conception

T/F: Polymorphisms affecting CYP enzymes are somatic mutations.

True

False

Which of the following cells lack a nucleus, and therefore cannot be used as a DNA source to test for germline polymorphisms? Select all that apply.

Choose one or more answers

red blood cells

platelets

white blood cells

epithelial cells

Patient RA has been taking tramadol for acute pain management, but states he has not been experiencing adequate pain relief. Which of the following testing analysis methods would you select to evaluate if RA's lack of analgesic effect is attributed to a CYP2D6 polymorphism?

whole genome sequencing

whole exome sequencing

target variant analysis

Which of the following is an advantage of using buccal swabs as a DNA sample collection?

results in higher DNA yields than peripheral blood collection

noninvasive and easy to perform

low risk of nonhuman DNA contamination

T/F: Various ethnic groups will have different allele frequencies for a given gene.

True

False

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PGx Week 11 Practice Quiz: Methods of PGx Testing

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PGx Week 11 Practice Quiz: Methods of PGx TestingVersión en línea

por Sophia

Which of the following accurately describe a germline polymorphism?

T/F: Polymorphisms affecting CYP enzymes are somatic mutations.

Which of the following cells lack a nucleus, and therefore cannot be used as a DNA source to test for germline polymorphisms? Select all that apply.

Choose one or more answers

Patient RA has been taking tramadol for acute pain management, but states he has not been experiencing adequate pain relief. Which of the following testing analysis methods would you select to evaluate if RA's lack of analgesic effect is attributed to a CYP2D6 polymorphism?

Which of the following is an advantage of using buccal swabs as a DNA sample collection?

T/F: Various ethnic groups will have different allele frequencies for a given gene.

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