PGx Week 9 Practice Quiz: Phase II Metabolism

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Phase II Metabolism: UGT1A1, TPMP, NUDT15, NAT2

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Sophia

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PGx Week 9 Practice Quiz: Phase II MetabolismVersión en línea Phase II Metabolism: UGT1A1, TPMP, NUDT15, NAT2 por Sophia 1 Which of the following medications is impacted by UGT1A1 polymorphisms? a darunavir b atazanavir c azathioprine d ritonavir 2 Which of the following medications are impacted by TPMT and NUDT15 polymorphisms? Select all that apply. Choose one or more answers a azathioprine b doxorubicin c 6-mercaptopurine d methotrexate e 5-fluorouracil f irinotecan 3 Which of the following medications is affected by NAT2 polymorphisms? a atazanavir b hydralazine c rifampin d nitroprusside 4 What is the primary risk of giving atazanavir to a patient who is a UGT1A1 poor metabolizer? a no risk b decreased antiviral efficacy leading to therapeutic failure c lupus-like syndrome d jaundice e bone marrow suppression f hand-foot syndrome 5 What is the best definition of Phase II drug metabolism? a The process by which drugs are excreted unchanged by the kidneys. b The enzymatic conversion of drugs into more lipid-soluble compounds for easier absorption. c The oxidation, reduction, or hydrolysis of drugs to introduce or expose functional groups. d The conjugation of drugs or their metabolites with endogenous substrates to increase water solubility and promote excretion.

PGx Week 9 Practice Quiz: Phase II MetabolismVersión en línea

Phase II Metabolism: UGT1A1, TPMP, NUDT15, NAT2

por Sophia

Which of the following medications is impacted by UGT1A1 polymorphisms?

darunavir

atazanavir

azathioprine

ritonavir

Which of the following medications are impacted by TPMT and NUDT15 polymorphisms? Select all that apply.

Choose one or more answers

azathioprine

doxorubicin

6-mercaptopurine

methotrexate

5-fluorouracil

irinotecan

Which of the following medications is affected by NAT2 polymorphisms?

atazanavir

hydralazine

rifampin

nitroprusside

What is the primary risk of giving atazanavir to a patient who is a UGT1A1 poor metabolizer?

no risk

decreased antiviral efficacy leading to therapeutic failure

lupus-like syndrome

jaundice

bone marrow suppression

hand-foot syndrome

What is the best definition of Phase II drug metabolism?

The process by which drugs are excreted unchanged by the kidneys.

The enzymatic conversion of drugs into more lipid-soluble compounds for easier absorption.

The oxidation, reduction, or hydrolysis of drugs to introduce or expose functional groups.

The conjugation of drugs or their metabolites with endogenous substrates to increase water solubility and promote excretion.

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PGx Week 9 Practice Quiz: Phase II Metabolism

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PGx Week 9 Practice Quiz: Phase II MetabolismVersión en línea

por Sophia

Which of the following medications is impacted by UGT1A1 polymorphisms?

Which of the following medications are impacted by TPMT and NUDT15 polymorphisms? Select all that apply.

Choose one or more answers

Which of the following medications is affected by NAT2 polymorphisms?

What is the primary risk of giving atazanavir to a patient who is a UGT1A1 poor metabolizer?

What is the best definition of Phase II drug metabolism?

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