PGx Week 8 Practice Quiz: CYP2D6

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CYP2D6 Part 2: Tricyclic Antidepressants and Phenoconversion

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Sophia

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PGx Week 8 Practice Quiz: CYP2D6Versión en línea CYP2D6 Part 2: Tricyclic Antidepressants and Phenoconversion por Sophia 1 Which of the following TCAs are affected by both CYP2D6 AND CYP2C19 polymorphisms? Select all that apply. Choose one or more answers a amitriptyline b clomipramine c desipramine d nortriptyline e trimipramine 2 According to CPIC guidelines, for which CYP2D6 metabolism status is an alternative to ondansetron recommended? a Ultrarapid metabolism b Rapid metabolism c Intermediate metabolism d Poor metabolism 3 Which of the following medications are affected by CYP2D6 polymorphism? Select all that apply. Choose one or more answers a aripiprazole b atomoxetine c granisetron d omeprazole e sertraline f tramadol 4 Patient FS is a CYP2D6 normal metabolizer. However, they are currently taking bupropion, a strong CYP2D6 inhibitor. Which of the following best describes the patient’s likely CYP2D6 metabolic phenotype while on bupropion? a Ultrarapid metabolizer b Rapid metabolizer c Normal metabolizer d Intermediate metabolizer e Poor metabolizer 5 For patient FS who is a genotyped CYP2D6 normal metabolizer, but taking bupropion (strong CYP2D6 inhibitor), which of the following medications should be avoided? a citalopram b codeine c morphine d sertraline

PGx Week 8 Practice Quiz: CYP2D6Versión en línea

CYP2D6 Part 2: Tricyclic Antidepressants and Phenoconversion

por Sophia

Which of the following TCAs are affected by both CYP2D6 AND CYP2C19 polymorphisms? Select all that apply.

Choose one or more answers

amitriptyline

clomipramine

desipramine

nortriptyline

trimipramine

According to CPIC guidelines, for which CYP2D6 metabolism status is an alternative to ondansetron recommended?

Ultrarapid metabolism

Rapid metabolism

Intermediate metabolism

Poor metabolism

Which of the following medications are affected by CYP2D6 polymorphism? Select all that apply.

Choose one or more answers

aripiprazole

atomoxetine

granisetron

omeprazole

sertraline

tramadol

Patient FS is a CYP2D6 normal metabolizer. However, they are currently taking bupropion, a strong CYP2D6 inhibitor. Which of the following best describes the patient’s likely CYP2D6 metabolic phenotype while on bupropion?

Ultrarapid metabolizer

Rapid metabolizer

Normal metabolizer

Intermediate metabolizer

Poor metabolizer

For patient FS who is a genotyped CYP2D6 normal metabolizer, but taking bupropion (strong CYP2D6 inhibitor), which of the following medications should be avoided?

citalopram

codeine

morphine

sertraline

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PGx Week 8 Practice Quiz: CYP2D6

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PGx Week 8 Practice Quiz: CYP2D6Versión en línea

por Sophia

Which of the following TCAs are affected by both CYP2D6 AND CYP2C19 polymorphisms? Select all that apply.

Choose one or more answers

According to CPIC guidelines, for which CYP2D6 metabolism status is an alternative to ondansetron recommended?

Which of the following medications are affected by CYP2D6 polymorphism? Select all that apply.

Choose one or more answers

Patient FS is a CYP2D6 normal metabolizer. However, they are currently taking bupropion, a strong CYP2D6 inhibitor. Which of the following best describes the patient’s likely CYP2D6 metabolic phenotype while on bupropion?

For patient FS who is a genotyped CYP2D6 normal metabolizer, but taking bupropion (strong CYP2D6 inhibitor), which of the following medications should be avoided?

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