FGT & Ovary

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Bakiarathana

India

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FGT & Ovary


FGT & OvaryVersión en línea Lets begin por Bakiarathana 1 A 38-year-old woman presents with post-coital bleeding. Per speculum exam reveals a friable lesion on the cervix. Pap smear shows atypical squamous cells with hyperchromatic nuclei and coarse chromatin. HPV DNA testing is positive for type 16.Which of the following best explains the pathogenesis of her condition? a Integration of high-risk HPV DNA into host genome b Chronic estrogen stimulation c TP53 mutation d BRCA1 gene mutation 2 A 42-year-old nulliparous woman complains of heavy menstrual bleeding and pelvic pressure. Ultrasound shows a 6 cm hypoechoic mass in the uterine wall. Which of the following features best supports a diagnosis of leiomyoma over leiomyosarcoma? a Well-circumscribed margins with whorled pattern b High mitotic activity c Nuclear atypia d Infiltrative borders 3 A 52-year-old obese woman presents with postmenopausal bleeding. Endometrial biopsy shows increased gland-to-stroma ratio with nuclear atypia. What is the most likely precursor lesion in her case? a Atypical endometrial hyperplasia (EIN) b Serous endometrial intraepithelial carcinoma c Simple hyperplasia without atypia d Chronic cervicitis 4 A 60-year-old postmenopausal woman presents with abdominal bloating. Imaging reveals a 10 cm complex cystic ovarian mass with papillary projections. Histopathology shows stratified epithelium with nuclear atypia and psammoma bodies.Which of the following is the most likely diagnosis? a High-grade serous carcinoma b Serous cystadenoma c Mucinous cystadenoma d Granulosa cell tumor 5 A 30-year-old woman has severe dysmenorrhea and dyspareunia. Pelvic laparoscopy reveals "chocolate cysts" on ovaries.What histological triad confirms the diagnosis? a Glands, stroma, hemosiderin-laden macrophages b Atypical epithelial cells, calcification, fibrosis c Stroma, muscle fibers, fibrosis d Villi, glands, inflammation 6 A 45-year-old woman presents with bilateral ovarian enlargement and weight loss. Ovarian biopsy shows mucin-filled signet ring cells.Which is the most likely primary site? a Stomach b Endometrium c Colon d Pancreas 7 A 26-year-old woman presents with abnormal uterine bleeding and very high serum β-hCG levels. She had a history of complete molar pregnancy 3 months ago. Uterine mass is vascular and necrotic.Which histological feature supports the diagnosis? a Cytotrophoblasts and syncytiotrophoblasts without villi b Well-formed chorionic villi c Sheets of intermediate trophoblasts only d Atypical squamous cells 8 A 20-year-old woman presents with an abdominal mass. CT reveals a solid ovarian tumor. Histology shows sheets of large cells with clear cytoplasm and central nuclei. Serum LDH is elevated.Which of the following markers is most likely positive? a PLAP b β-hCG c AFP d Inhibin 9 A 55-year-old postmenopausal woman has vaginal bleeding. Ultrasound shows an ovarian mass. Endometrial biopsy reveals hyperplasia.Which of the following is a histologic hallmark of the tumor? a Call-Exner bodies b Schiller-Duval bodies c Psammoma bodies d Syncytiotrophoblasts 10 A 25-year-old woman presents with fever, lower abdominal pain, and cervical motion tenderness. Her menstrual history is irregular. Labs show leukocytosis.Which of the following is a long-term complication of this condition? a Infertility due to tubal scarring b Leiomyoma c Adenomyosis d Cervical cancer Feedback 1 High-risk HPV types (16, 18) integrate their DNA into host cells, leading to expression of E6 and E7 oncoproteins, which inactivate p53 and Rb, promoting cervical carcinogenesis. 2 Leiomyomas are benign smooth muscle tumors showing whorled bundles of spindle cells without atypia or high mitoses. 3 Atypical hyperplasia is considered a precursor to endometrioid-type endometrial carcinoma. 4 High-grade serous carcinoma shows complex papillary architecture, nuclear pleomorphism, and psammoma bodies; commonly seen in postmenopausal women. 5 Classic histological features of endometriosis include endometrial glands, stroma, and hemorrhage (with hemosiderin). 6 Krukenberg tumor is a metastatic mucinous adenocarcinoma, most commonly from gastric origin, with signet ring cells. 7 Choriocarcinoma lacks chorionic villi and is composed of proliferating cytotrophoblasts and syncytiotrophoblasts. 8 Dysgerminomas are germ cell tumors positive for PLAP and OCT3/4. 9 Granulosa cell tumors may secrete estrogen and show microfollicular structures (Call-Exner bodies). 10 PID can lead to salpingitis and tubo-ovarian adhesions, resulting in infertility.

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FGT & Ovary

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Tipos de sintagmas (II)

FGT & OvaryVersión en línea

por Bakiarathana

A 42-year-old nulliparous woman complains of heavy menstrual bleeding and pelvic pressure. Ultrasound shows a 6 cm hypoechoic mass in the uterine wall. Which of the following features best supports a diagnosis of leiomyoma over leiomyosarcoma?

A 52-year-old obese woman presents with postmenopausal bleeding. Endometrial biopsy shows increased gland-to-stroma ratio with nuclear atypia. What is the most likely precursor lesion in her case?

A 60-year-old postmenopausal woman presents with abdominal bloating. Imaging reveals a 10 cm complex cystic ovarian mass with papillary projections. Histopathology shows stratified epithelium with nuclear atypia and psammoma bodies.Which of the following is the most likely diagnosis?

A 30-year-old woman has severe dysmenorrhea and dyspareunia. Pelvic laparoscopy reveals "chocolate cysts" on ovaries.What histological triad confirms the diagnosis?

A 45-year-old woman presents with bilateral ovarian enlargement and weight loss. Ovarian biopsy shows mucin-filled signet ring cells.Which is the most likely primary site?

A 26-year-old woman presents with abnormal uterine bleeding and very high serum β-hCG levels. She had a history of complete molar pregnancy 3 months ago. Uterine mass is vascular and necrotic.Which histological feature supports the diagnosis?

A 20-year-old woman presents with an abdominal mass. CT reveals a solid ovarian tumor. Histology shows sheets of large cells with clear cytoplasm and central nuclei. Serum LDH is elevated.Which of the following markers is most likely positive?

A 55-year-old postmenopausal woman has vaginal bleeding. Ultrasound shows an ovarian mass. Endometrial biopsy reveals hyperplasia.Which of the following is a histologic hallmark of the tumor?

A 25-year-old woman presents with fever, lower abdominal pain, and cervical motion tenderness. Her menstrual history is irregular. Labs show leukocytosis.Which of the following is a long-term complication of this condition?

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