Hypothesis vs. PredictionVersión en línea The Global Epidemic of Confusing Hypotheses with Predictions Fixing an International Problem We routinely use the term hypothesis when we mean prediction. This unacceptable substitution dilutes the power of the scientific method to the extent that invoking the scientific method has become largely meaningless Guy McPherson, American Biology Teacher, April 2001 por Juan CARLOS MONTOYA LOPEZ 1 Hypothesis 2 Predictions Because of their small mass and the surface tension of water, springtails on the surface of a tidepool stick to each other via the ‘Cheerios effect’ (Vella and Mahadevan, 2005). Springtails tend to paddle toward their nearest neighbor, which over time leads to rafts a positive-feedback loop exists between the preferences of the host for a particular dietary regimen, the composition of the gut microbiota that depends on this regimen, and the preferences of the host as influenced by the gut microbiota the gut microbiota populations are sensitive to genetic and environmental influences, and can produce or influence afferent signals that directly or indirectly impinge on energy homeostatic systems affecting both energy balance (weight gain or loss) and energy stores. alterations in gut microbiota diversity and composition contribute to the pathogenesis of obesity and obesity-related metabolic disorders. Because the Cheerios effect relies on surface tension, lowering the surface tension of water with a surfactant will stop springtails from aggregating. Immobilizing the springtails will abolish raft formation. . If food intake determines the gut microbiota, feasting and fasting, the two most extreme dietary lifestyles, should be expected to produce major changes in the microbiota. transplanting distal gut communities from genetically obese ob/ob mice, or diet-induced obese mice is sufficient to recapitulate the obese phenotype in the recipient mouse.