Relacionar Columnas Chapter 17 Innate, nonspecific Host DefensesVersión en línea chapter 17 vocabulary por Janet Marticorena 1 Innate response 2 Plasma contains: 3 Physical barriers 4 Immunity 5 purpose of immune system 6 Chemical barriers 7 Adaptive response 8 Serum contains: skin, mucus membranes, cilia, flushing, reflexes, normal flora/ microbiome b cells, t cells, chemical components stomach acid, lysozyme, low ph from ear wax and fatty acids barriers, eliminators, chemical components surveillance of the body, recognition of foreign invaders and material, destruction of foregin invaders a state of having sufficient biological defenses to avoid infection, disease or other unwanted biological invasion complement proteins, antibodies, molecules not related to defense clotting factors, complement proteins, antibodies 1 Monocyte 2 Alveolar macrophage 3 PAMPs 4 PRR 5 Microglial 6 Neutrophils 7 Cytokines pathogen-associated molecular patterns, things on the exterior part of pathogen that cause a response pattern recognition receptor, receptors on phagocytic cells that recognize PAMPs, Toll-like receptors in the blood in the brain signaling molecules secreated by many different immune cells most abundant white blood cell in the blood, engulf and destroy bacteria, uses NETS, make pus formation in the lungs 1 2- 2 3 3 1- injured/infected cells secrete chemical signals into the blood, what happend next? the leukocytes squeeze between the cells of the capillary wall as they follow the chemical signals to where they are most concentrated neutrophils releases cytotoxic chemicals from granules into tissue leukocytes in the blood respond to chemical attractants released by pathogens and chemical signal from nearby injured cells 1 Swelling 2 Pain 3 exogenous pyrogens 4 endogenous pyrogens 5 Redness 6 Warmth pathogen trigger or something else trigger it (tumor) because all the extra volume (dolor) the nerves become pinched (rubor) due to lots of blood to the area (calor) because the blood comes from the core you trigger it, our own cells trigger it 1 3 ways to activate complement system 2 Complement system 3 3 outcomes of complement activation 4 Natural killer cells stimulation of inflammation, opsonization and membrane attack complex cell recognizes MHC1 on a healthy cell and does not kill it but on infected cell does not present MHC1 it kills it a series of proteins in the blood that complements other immune functions classical, alternative, mannose-lectin pathways
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