Relacionar Columnas Cholesterol pharmacologyVersión en línea Cholesterol pharmacology por Ashleigh Pell 1 statin side effects 2 most potent statin 3 standard statin 4 statin with less drug interactions 5 What statins do, and where 6 statin indication 7 What does the enzyme HMG-CoA do? 8 statin warning 9 with less cholesterol synthesis, what does the liver do? increases hepatic synthesis of cholesterol increases the uptake of low-density lipoprotein (LDL) from the blood simvastatin atorvastatin myalgia/headache/GI symptoms high lipids / LDL pravastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. inhibit HMG-CoA reductase in the liver 1 alirocumab indication 2 ezetimisbe side effect 3 fenofibrate side effects 4 fenofibrate contra-indication 5 fenofibrate caution 6 Alirocumab side effects 7 fenofibrate causes lipolysis because 8 Fenofibrate indication 9 Alirocumab inhibits 10 ezetimibe inhibits 11 fenofibrate activates intestinal cholesterol absorption weakness/GI upset/headaches gall bladder disease, pancreatitis PPARα's genes code for peroxisomes which participate in lipolysis myotoxicity if improper dose or renal impairment. familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors nuclear receptor PPARα which begins gene transcription and translation flu-like symptoms GI upset/vomiting high serum triglycerides
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