Relacionar Columnas Cholesterol pharmacologyVersión en línea Cholesterol pharmacology por Ashleigh Pell 1 statin warning 2 What statins do, and where 3 most potent statin 4 statin side effects 5 statin with less drug interactions 6 standard statin 7 What does the enzyme HMG-CoA do? 8 with less cholesterol synthesis, what does the liver do? 9 statin indication increases hepatic synthesis of cholesterol myalgia/headache/GI symptoms inhibit HMG-CoA reductase in the liver pravastatin increases the uptake of low-density lipoprotein (LDL) from the blood atorvastatin Grapefruit inhibits cytochrome P450, increasing statin bioavailability. high lipids / LDL simvastatin 1 fenofibrate caution 2 ezetimisbe side effect 3 Alirocumab inhibits 4 fenofibrate activates 5 fenofibrate side effects 6 ezetimibe inhibits 7 fenofibrate contra-indication 8 fenofibrate causes lipolysis because 9 Alirocumab side effects 10 alirocumab indication 11 Fenofibrate indication nuclear receptor PPARα which begins gene transcription and translation familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective PPARα's genes code for peroxisomes which participate in lipolysis weakness/GI upset/headaches flu-like symptoms intestinal cholesterol absorption inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors gall bladder disease, pancreatitis myotoxicity if improper dose or renal impairment. GI upset/vomiting high serum triglycerides
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