Cholesterol pharmacology

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Ashleigh Pell

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Relacionar Columnas Cholesterol pharmacologyVersión en línea Cholesterol pharmacology por Ashleigh Pell 1 What statins do, and where 2 standard statin 3 statin with less drug interactions 4 statin side effects 5 What does the enzyme HMG-CoA do? 6 with less cholesterol synthesis, what does the liver do? 7 most potent statin 8 statin warning 9 statin indication atorvastatin inhibit HMG-CoA reductase in the liver Grapefruit inhibits cytochrome P450, increasing statin bioavailability. myalgia/headache/GI symptoms increases hepatic synthesis of cholesterol increases the uptake of low-density lipoprotein (LDL) from the blood high lipids / LDL pravastatin simvastatin 1 fenofibrate side effects 2 fenofibrate contra-indication 3 ezetimibe inhibits 4 fenofibrate causes lipolysis because 5 Fenofibrate indication 6 fenofibrate activates 7 Alirocumab side effects 8 alirocumab indication 9 Alirocumab inhibits 10 ezetimisbe side effect 11 fenofibrate caution nuclear receptor PPARα which begins gene transcription and translation myotoxicity if improper dose or renal impairment. gall bladder disease, pancreatitis PPARα's genes code for peroxisomes which participate in lipolysis familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective intestinal cholesterol absorption GI upset/vomiting flu-like symptoms weakness/GI upset/headaches high serum triglycerides inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors

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Cholesterol pharmacologyVersión en línea

Cholesterol pharmacology

por Ashleigh Pell

What statins do, and where

standard statin

statin with less drug interactions

statin side effects

What does the enzyme HMG-CoA do?

with less cholesterol synthesis, what does the liver do?

most potent statin

statin warning

statin indication

atorvastatin

inhibit HMG-CoA reductase in the liver

Grapefruit inhibits cytochrome P450, increasing statin bioavailability.

myalgia/headache/GI symptoms

increases hepatic synthesis of cholesterol

increases the uptake of low-density lipoprotein (LDL) from the blood

high lipids / LDL

pravastatin

simvastatin

fenofibrate side effects

fenofibrate contra-indication

ezetimibe inhibits

fenofibrate causes lipolysis because

Fenofibrate indication

fenofibrate activates

Alirocumab side effects

alirocumab indication

Alirocumab inhibits

ezetimisbe side effect

fenofibrate caution

nuclear receptor PPARα which begins gene transcription and translation

myotoxicity if improper dose or renal impairment.

gall bladder disease, pancreatitis

PPARα's genes code for peroxisomes which participate in lipolysis

familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective

intestinal cholesterol absorption

GI upset/vomiting

flu-like symptoms

weakness/GI upset/headaches

high serum triglycerides

inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors

Cholesterol pharmacology

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Cholesterol pharmacologyVersión en línea

por Ashleigh Pell

What statins do, and where

standard statin

statin with less drug interactions

statin side effects

What does the enzyme HMG-CoA do?

with less cholesterol synthesis, what does the liver do?

most potent statin

statin warning

statin indication

fenofibrate side effects

fenofibrate contra-indication

ezetimibe inhibits

fenofibrate causes lipolysis because

Fenofibrate indication

fenofibrate activates

Alirocumab side effects

alirocumab indication

Alirocumab inhibits

ezetimisbe side effect

fenofibrate caution