Relacionar Columnas Cholesterol pharmacologyVersión en línea Cholesterol pharmacology por Ashleigh Pell 1 with less cholesterol synthesis, what does the liver do? 2 statin side effects 3 standard statin 4 What does the enzyme HMG-CoA do? 5 statin with less drug interactions 6 What statins do, and where 7 statin warning 8 statin indication 9 most potent statin simvastatin increases the uptake of low-density lipoprotein (LDL) from the blood atorvastatin inhibit HMG-CoA reductase in the liver high lipids / LDL Grapefruit inhibits cytochrome P450, increasing statin bioavailability. pravastatin myalgia/headache/GI symptoms increases hepatic synthesis of cholesterol 1 ezetimisbe side effect 2 fenofibrate caution 3 fenofibrate activates 4 ezetimibe inhibits 5 Alirocumab side effects 6 fenofibrate contra-indication 7 Fenofibrate indication 8 fenofibrate causes lipolysis because 9 fenofibrate side effects 10 Alirocumab inhibits 11 alirocumab indication GI upset/vomiting gall bladder disease, pancreatitis nuclear receptor PPARα which begins gene transcription and translation flu-like symptoms PPARα's genes code for peroxisomes which participate in lipolysis myotoxicity if improper dose or renal impairment. weakness/GI upset/headaches familial hypercholesterolaemia, high risk, statins and ezetimibe ineffective high serum triglycerides intestinal cholesterol absorption inhibits PCSK9, a liver protein that regulates/breaks down LDL receptors
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