The
prognosis
is
generally
excellent
.
This
is
especially
true
____________________
disseminated
superficial
porokeratosis
(
DSP
)
.
Large
lesions
of
____________________
,
linear
porokeratosis
,
or
porokeratosis
in
an
immunocompromised
patients
should
be
____________________
carefully
for
the
development
of
cutaneous
malignancies
____________________
the
porokeratosis
lesions
.
Malignant
transformation
can
occur
in
about
7
.
5%
____________________
patients
.
Lesions
that
____________________
large
,
long
-
standing
,
or
linear
have
the
greatest
risk
of
____________________
an
associated
malignancy
.
Chromosomal
instability
and
____________________
immune
surveillance
with
overexpression
of
p53
are
hypothesized
to
____________________
a
role
in
the
development
of
cutaneous
malignancies
within
porokeratosis
.
Porokeratosis
of
Mibelli
(
PM
)
circumferentially
involving
the
digits
may
induce
pseudoainhum
.
Most
lesions
are
asymptomatic
.
Ulcerative
lesions
have
____________________
described
.
Giant
PM
in
a
facial
or
acral
location
____________________
cause
destruction
of
underlying
soft
tissue
or
pseudoainhum
with
amputation
.
