Pemphigoid
gestationis
is
a
pregnancy
-
associated
autoimmune
disease
.
Most
patients
develop
antibodies
against
the
hemidesmosomal
protein
BP180
(
BPAG2
,
collagen
XVII
)
,
____________________
,
in
some
cases
,
antibodies
also
form
against
another
hemidesmosomal
protein
,
BP230
.
However
,
whereas
the
role
of
anti
-
BP180
is
well
____________________
in
the
pathogenesis
of
pemphigoid
gestationis
,
BP230
is
intracellular
and
the
clinical
significance
of
anti
-
BP230
is
uncertain
.
Historically
____________________
as
herpes
gestationis
factor
,
these
circulating
antibodies
belong
to
the
heat
-
stable
immunoglobulin
G1
subclass
.
The
binding
of
immunoglobulin
G
to
the
basement
membrane
____________________
the
dermoepidermal
junction
triggers
an
immune
response
____________________
neutrophils
and
eosinophils
,
leading
to
the
formation
____________________
subepidermal
vesicles
and
blisters
.
In
1999
,
Chimanovitch
et
al
demonstrated
that
pemphigoid
gestationis
sera
____________________
five
distinct
epitopes
within
BP180
NC16A
,
four
of
which
have
been
____________________
as
major
antigenic
sites
targeted
by
bullous
pemphigoid
antibodies
.
