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1. The main reasons for treating symptoms of the menopausal transition and actual menopause are as follows:
2. In the Women’s Health Initiative (WHI), greater safety and possible benefit from hormone or estrogen therapy for women in their 50s, with potential harm for older women, were observed with respect to the following
3. Administration routes for hormone therapy are as follows:
4. Contraindications for estrogen therapy include the following:

To preserve bone

Colorectal cancer

Topical

Coronary artery disease (CAD)

Severe liver disease

To improve quality of life

Pregnancy

To reduce the risk of unwanted pregnancy

Personal history of breast cancer

To lower the risk of disease

Oral

Total myocardial infarction

To avoid the irregularity of menstrual cycles

Total mortality

Venous thrombosis

Transdermal

Undiagnosed vaginal bleeding

Vaginal route cream, ring, or tablet for vaginal symptoms

Global index of chronic diseases

To provide relief of vasomotor symptoms