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Mitral stenosis ( MS ) is characterized by obstruction to left ventricular ____________________ at the level of mitral valve due to structural ____________________ of the mitral valve apparatus . The most common ____________________ of mitral stenosis is rheumatic fever . The association of atrial septal defect with rheumatic mitral stenosis is ____________________ Lutembacher syndrome .
Stenosis of the mitral valve typically occurs decades ____________________ the episode of acute rheumatic carditis . Acute insult ____________________ to formation of multiple inflammatory foci ( Aschoff bodies , perivascular mononuclear infiltrate ) in the endocardium and ____________________ . Small vegetations along the border of the valves may also be ____________________ . With time , the valve apparatus becomes thickened , calcified , and contracted , and commissural adhesion occurs , ultimately resulting in stenosis .
Whether the ____________________ of valve damage is due to hemodynamic injury of the already ____________________ valve apparatus or to the chronic inflammatory nature of the ____________________ process is unclear .