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1. The optimal medical therapy for the treatment of idiopathic pulmonary fibrosis has yet to be identified.
2. Pharmacotherapy

Tyrosine kinase inhibitors (eg, nintedanib)

Systemic corticosteroids (eg, prednisone)

Vaccinate patients against influenza and pneumococcal infection.

Prescribe oxygen therapy in patients with hypoxemia at rest or with exercise (partial pressure of oxygen [PaO2] < 55 mmHg or an oxygen saturation by pulse oximetry [SpO2] < 88%). The goal is to maintain an oxygen saturation of at least 90% at rest, with sleep, and with exertion.

Antifibrotic agents (eg, pirfenidone)

Encourage tobacco users to quit and offer pharmacotherapy as needed.

Immunosuppressant agents (eg, azathioprine, cyclophosphamide)