Sex/race/ethnicity:
Acute syndromes:
Adenopathy:
Chronic presentation:
History:
Chronic syndromes:
Location:
Clinical course:
Antigen testing:
Immunosuppressed presentation:
Serology:
CBC count:
Acute/subacute presentation:
Physical examination:
Diffuse disease.
Large exposure includes construction sites, birds, caves; low exposure includes living in an endemic area
Cavitary pulmonary lung disease, calcified lymph nodes, mediastinal fibrosis
Lung infiltrate, lobar pneumonia, micronodular pattern
Common, granulomatous mediastinal involvement, can be profound, can calcify
Useful in testing immunocompetent individuals with acute or subacute disease.
Uncommon findings include erythema nodosum and erythema multiforme
Pneumonia, disseminated disease in immunocompromised persons
Usually asymptomatic (if symptoms occur they are nonspecific); symptoms 3 months indicate chronic disease
Thrombocytopenia in disseminated disease
Cavitary lung lesions
Midwestern United States, Southeastern United States, Central America, Eastern Canada
Useful in testing infiltrative or chronic disease in immunosuppressed; urine antigen has ~60% sensitivity; serum antigen has ~60% sensitivity; both combined have >80% sensitivity
No predisposition
