Hirschsprung
disease
is
a
developmental
disorder
characterized
by
the
____________________
of
ganglia
in
the
distal
colon
,
resulting
in
____________________
functional
obstruction
.
See
the
images
below
.
Most
cases
of
Hirschsprung
disease
are
diagnosed
in
the
newborn
period
.
Hirschsprung
disease
should
be
considered
____________________
any
newborn
who
fails
to
pass
meconium
within
24
-
48
hours
of
birth
.
____________________
contrast
enema
is
useful
in
establishing
the
diagnosis
,
full
-
thickness
rectal
biopsy
____________________
the
criterion
standard
.
Once
the
diagnosis
is
____________________
,
the
definitive
treatment
is
to
remove
the
aganglionic
bowel
and
____________________
restore
continuity
of
the
healthy
bowel
____________________
the
distal
rectum
,
with
or
without
an
initial
intestinal
diversion
.
