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Endoscopic characteristics
However , while Paull et al's ____________________ clarified the nature of the histologic lesion , the ____________________ definition of Barrett esophagus has continued to change . ____________________ people believed that the distal esophagus could contain a ____________________ region of columnar mucosa . In addition , determining the ____________________ location of the esophagogastric junction ( EGJ ) ____________________ patients with Barrett esophagus often is difficult . To ____________________ false - positive diagnoses , investigators selected arbitrary lengths of ____________________ - ____________________ esophagus to establish a diagnosis for their studies . ____________________ , community endoscopists embraced this practice , and biopsy of the ____________________ - ____________________ normal distal columnar - lined esophagus was avoided .
Convincing evidence ____________________ that SIM , the hallmark histologic lesion of Barrett ____________________ , predisposes to dysplasia and cancer regardless of the ____________________ location . Thus , the definition of Barrett esophagus currently ____________________ the finding of SIM anywhere within the ____________________ esophagus .