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Barrett esophagus is well recognized as a complication of ____________________ reflux disease ( GERD ) . Prolonged exposure of the esophagus to ____________________ refluxate of GERD can erode the esophageal mucosa , ____________________ inflammatory cell infiltrate , and ultimately cause epithelial necrosis . ____________________ chronic damage is believed to promote the replacement of ____________________ esophageal epithelium with the metaplastic columnar cells of ____________________ esophagus . Why only some people with GERD ____________________ Barrett esophagus is not clea r