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CENP-A

CENP-C

Polo-Box Domain (PBD)

Mis18 Complex

HJURP

Centromere

PLK1

CDK

Specialized region of the chromosome that provides a base for kinetochore formation in mitosis

Dedicated CENP-A deposition machinery

Constitutive centromere-associated protein that binds M18BP1

Histone H3 variant deposited at centromeres

Kinase that inhibits Mis18 complex formation

Kinase that phosphorylates M18BP1 to license CENP-A deposition

Necessary for PLK1 localization to centromeres

CENP-A chaperone