catalyze synthesis of rRNA
Alpha Thalassemia Both fetus (HbF) and (HbA), defective remodeling and spacing protein
Amanita Phalloides
patient who present with flushing, high blood calcitonin level, exhibit alternative mRNA splicing
inhibit elongation, intercalated near G residue
Betal Thalassemia in Ch 11
synthesis hnRNA (nuclear RNA)
makes antibodies to DNA and SnRNA-binding protein
alpha helix, zinc finger, helix turn helix catalyze histone acetylation/deacetylation, recruit coactivators and corepressors.
a-amanitin
RNA polymerase I
inhibit RNA pol II
Transcription Factors
Actinomycin D
Death cap mushroom inhibit pol II and III, microfilament are stabilized . gastric lavage.
Butterfly shaped rash. Systemic Lupus Erythematosus
Medullary Thyroid Cancer
result from hnRNA Splicing defect, hnRNA Cap site defect, poly(A) signal defect.
Defect on Ch. 16
RNA polymerase II